1. As You like It

If you're sick of being friends with someone, say, "I do desire we may be better strangers." It lets them know that you'd rather have them out of your life than in it. They're doing nothing for you, so why would you want to associate with them? This is one of the Shakespearean insults that tells it like it is.

2. Coriolanus

Instead of calling someone a baby, or saying that they’re childish, tell them that their, "abilities are too infant-like for doing much alone." It's a fancy way of saying that they're incapable of acting like an adult. They need help with every activity, because they aren't the least bit mature.

3. Coriolanus - Part 2

"There is no more mercy in him than there is milk in a male tiger." This insult is a little hard to incorporate into conversation, but you can replace the word 'mercy' with anything you'd like. Try substituting it for 'beauty' or 'kindness.' It'll still hold all of the power Shakespeare intended it to, but will have a slightly different meaning.

4. Henry VI

"Take her away; for she hath lived too long, to fill the world with vicious qualities." This is a clever way to say that someone is a bad person. They have horrible qualities that they should be punished for, and you're alerting everyone of the fact.

5. Henry VI - Part 2

"Teeth hadst thou in thy head when thou wast born, to signify thou camest to bite the world." This is an insult you don't hear too often, which is why everyone will remember hearing you say it. It's basically claiming that it was clear from their birth that they were going to be nothing but trouble to the world.

6. Richard III

"Thou unfit for any place but hell." This is a line that you can use in plenty of different situations. Even if your friends aren't Shakespeare fans, they'll understand this quote. It's quite clear, so they won't have to look up its meaning in order to get your point.

7. Richard III - Part 2

Why stick to old, boring insults when you can use some classy Shakespeare sayings? Instead of calling someone ugly, all you have to say is, "Out of my sight! Thou dost infect my eyes." It's a more subtle way to say that you can't stand looking at them, whether it's due to their looks or their awful personality.

If you're going to jokingly insult your friends, you might as well do so in the cleverest way possible. Use these legendary Shakespeare quotes in order to put your pals in their place. What's your favorite play written by Shakespeare? What about your favorite quote? There are hundreds of them out there, so this list is only a small portion of the man's greatest writing.
Source: shakespeare-online.com